Laura Jacobsen

Laura Jacobsen, M.D.

Assistant Professor

Department: MD-PEDS-ENDOCRINOLOGY
Business Phone: (352) 265-7337
Business Email: lauraj@ufl.edu

About Laura Jacobsen

Hello, my name is Laura Jacobsen and I am an assistant professor and pediatric endocrinologist. I joined the University of Florida faculty in 2018 in the department of pediatrics. I was inspired to become a physician when I volunteered at the Florida Diabetes Camp and found my passion for caring for children with complex medical conditions.

I completed my pediatric residency training at the University of North Carolina in Chapel Hill, which was followed by a pediatric endocrinology fellowship at the UF Health Shands Children’s Hospital in Gainesville, Florida. During my fellowship, I was recognized for excellence in medical student teaching, and received the Henry A. Kokomoor Outstanding Fellowship Award.

I provide clinical care for children with endocrine disorders and diabetes. I perform clinical and translational research in the field of Type 1 diabetes to better understand what causes Type 1 diabetes and ways to halt or prevent it. I am also conversational in American Sign Language. I aim to improve the lives of children and their families living with diabetes and endocrine conditions, not just medically but in all aspects of day-to-day life. Additionally, I strive to bring new therapies and technologies to individuals with type 1 diabetes.

When I am not working I enjoy spending time crocheting, playing soccer and visiting National parks.

Accomplishments

Excellence in Medical Student Education Pediatric Clerkship Rotation
2019 · UF Department of Pediatrics
Henry A. Kokomoor Outstanding Fellowship Award
2017 · UF Department of Pediatrics
Type 1 Diabetes TrialNet Emerging Leader
2017 · Type 1 Diabetes TrialNet
Floyd W. Denny Pediatric Society Resident Award for Excellence in Pediatric Care
2015 · UNC Department of Pediatrics
Johnny Carson Award for Best Overall Research Evening of Scholarship
2015 · UNC Department of Pediatrics
UF Chapman Chapter of the Gold Humanism Honor Society Inductee
2011 · UF College of Medicine

Teaching Profile

Courses Taught
2018
MDC7400 Pediatric Clerkship
2018
MDT7090 Elective Topics
2018
MDC6001 Intro Clin Practice

Board Certifications

  • Pediatric Endocrinology
    American Board of Pediatrics
  • Pediatrics
    American Board of Pediatrics

Clinical Profile

Specialties
  • Pediatrics
Subspecialties
  • Pediatric Endocrinology
Areas of Interest
  • Blood glucose monitoring
  • Pediatric pituitary and skull base services
  • Type 1 diabetes
  • Type 2 diabetes

Research Profile

Areas of Interest
  • Diabetes Technology
  • Immunology of Type 1 diabetes
  • Prevention and intervention trials in Type 1 diabetes
  • Type 1 Diabetes
Open Researcher and Contributor ID (ORCID)

0000-0002-5144-7836

Publications

2024
Comparisons of Metabolic Measures to Predict T1D vs. Detect a Preventive Treatment Effect in High-Risk Individuals.
The Journal of clinical endocrinology and metabolism. [DOI] 10.1210/clinem/dgae048. [PMID] 38267821.
2024
Early Metabolic Endpoints Identify Persistent Treatment Efficacy in Recent-Onset Type 1 Diabetes Immunotherapy Trials
Diabetes Care. 47(6):1048-1055 [DOI] 10.2337/dc24-0171.
2024
Low-Dose Antithymocyte Globulin: A Pragmatic Approach to Treating Stage 2 Type 1 Diabetes
Diabetes Care. 47(2):285-289 [DOI] 10.2337/dc23-1750. [PMID] 38117469.
2024
Prompt Recognition of New-Onset Type 1 Diabetes Is Everyone’s Responsibility—Even on Weekends
Diabetes Care. 47(4):646-648 [DOI] 10.2337/dci23-0096.
2023
Factors Associated With Achieving Target A1C in Children and Adolescents With Type 1 Diabetes: Findings From the T1D Exchange Quality Improvement Collaborative
Clinical Diabetes. 41(1):68-75 [DOI] 10.2337/cd22-0073. [PMID] 36714245.
2023
Human immune phenotyping reveals accelerated aging in type 1 diabetes
JCI Insight. 8(17) [DOI] 10.1172/jci.insight.170767. [PMID] 37498686.
2023
Longitudinal Trends in Glycemic Outcomes and Technology Use for Over 48,000 People with Type 1 Diabetes (2016–2022) from the T1D Exchange Quality Improvement Collaborative
Diabetes Technology & Therapeutics. 25(11):765-773 [DOI] 10.1089/dia.2023.0320.
2023
Phenotypes Associated With Zones Defined by Area Under the Curve Glucose and C-peptide in a Population With Islet Autoantibodies
Diabetes Care. 46(5):1098-1105 [DOI] 10.2337/dc22-2236. [PMID] 37000695.
2023
Responders to low-dose ATG induce CD4+ T cell exhaustion in type 1 diabetes
JCI Insight. 8(16) [DOI] 10.1172/jci.insight.161812. [PMID] 37432736.
2023
Type 1 Diabetes Continuous Glucose Monitoring Use in the Pediatric Emergency Department Affects Laboratory Test Frequency but Not Treatment Timing
Diabetes Spectrum. 36(3):275-280 [DOI] 10.2337/ds22-0061. [PMID] 37583555.
2023
Utility and precision evidence of technology in the treatment of type 1 diabetes: a systematic review.
Communications medicine. 3(1) [DOI] 10.1038/s43856-023-00358-x. [PMID] 37794113.
2022
ISPAD Clinical Practice Consensus Guidelines 2022: Stages of type 1 diabetes in children and adolescents
Pediatric Diabetes. 23(8):1175-1187 [DOI] 10.1111/pedi.13410.
2022
Accuracy of Three Commercial Home-Use Hemoglobin A1c Tests
Diabetes Technology & Therapeutics. 24(11):789-796 [DOI] 10.1089/dia.2022.0187.
2022
Age and Hospitalization Risk in People With Type 1 Diabetes and COVID-19: Data From the T1D Exchange Surveillance Study.
The Journal of clinical endocrinology and metabolism. 107(2):410-418 [DOI] 10.1210/clinem/dgab668. [PMID] 34581790.
2022
Cost-Effectiveness of Low-Dose Antithymocyte Globulin Versus Other Immunotherapies for Treatment of New-Onset Type 1 Diabetes
Diabetes Technology & Therapeutics. 24(4):258-267 [DOI] 10.1089/dia.2021.0329.
2022
Heterogeneity of DKA Incidence and Age-Specific Clinical Characteristics in Children Diagnosed With Type 1 Diabetes in the TEDDY Study
Diabetes Care. 45(3):624-633 [DOI] 10.2337/dc21-0422. [PMID] 35043162.
2022
Hybrid Closed-Loop Systems and Glycemic Outcomes in Children and Adults With Type 1 Diabetes: Real-World Evidence From a U.S.-Based Multicenter Collaborative.
Diabetes care. 45(8):e118-e119 [DOI] 10.2337/dc22-0329. [PMID] 35708494.
2022
Index60 Identifies Individuals at Appreciable Risk for Stage 3 Among an Autoantibody-Positive Population With Normal 2-Hour Glucose Levels: Implications for Current Staging Criteria of Type 1 Diabetes.
Diabetes care. 45(2):311-318 [DOI] 10.2337/dc21-0944. [PMID] 34853027.
2022
Index60 Is Superior to HbA1c for Identifying Individuals at High Risk for Type 1 Diabetes
The Journal of Clinical Endocrinology & Metabolism. 107(10):2784-2792 [DOI] 10.1210/clinem/dgac440. [PMID] 35880956.
2022
Learning experience design of an mHealth self-management intervention for adolescents with type 1 diabetes.
Educational technology research and development : ETR & D. 70(6):2171-2209 [DOI] 10.1007/s11423-022-10160-6. [PMID] 36278247.
2022
Making Diabetes Electronic Medical Record Data Actionable: Promoting Benchmarking and Population Health Improvement Using the T1D Exchange Quality Improvement Portal.
Clinical diabetes : a publication of the American Diabetes Association. 41(1):45-55 [DOI] 10.2337/cd22-0072. [PMID] 36714251.
2022
Persistence of β-Cell Responsiveness for Over Two Years in Autoantibody-Positive Children With Marked Metabolic Impairment at Screening.
Diabetes care. 45(12):2982-2990 [DOI] 10.2337/dc22-1362. [PMID] 36326757.
2021
A retrospective multisite examination of depression screening practices, scores, and correlates in pediatric diabetes care.
Translational behavioral medicine. 11(1):122-131 [DOI] 10.1093/tbm/ibz171. [PMID] 31764981.
2021
Adherence to oral glucose tolerance testing in children in stage 1 of type 1 diabetes: The TEDDY study
Pediatric Diabetes. 22(2):360-368 [DOI] 10.1111/pedi.13149. [PMID] 33179853.
2021
Barriers to retinopathy screening in youth and young adults with type 1 diabetes
Pediatric Diabetes. 22(3):469-473 [DOI] 10.1111/pedi.13171.
2021
How Do We Move Type 1 Diabetes Immunotherapies Forward During the Current COVID-19 Pandemic?
Diabetes. 70(5):1021-1028 [DOI] 10.2337/dbi20-0045. [PMID] 33632743.
2021
Index60 as an additional diagnostic criterion for type 1 diabetes.
Diabetologia. 64(4):836-844 [DOI] 10.1007/s00125-020-05365-4. [PMID] 33496819.
2021
Insulin immunotherapy for pretype 1 diabetes.
Current opinion in endocrinology, diabetes, and obesity. 28(4):390-396 [DOI] 10.1097/MED.0000000000000648. [PMID] 34091488.
2021
Low-Dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report
Diabetes. 70(5):1123-1129 [DOI] 10.2337/db20-1103. [PMID] 33632742.
2021
Monogenic Diabetes and Integrated Stress Response Genes Display Altered Gene Expression in Type 1 Diabetes
Diabetes. 70(8):1885-1897 [DOI] 10.2337/db21-0070. [PMID] 34035041.
2021
Multisite Examination of Depression Screening Scores and Correlates Among Adolescents and Young Adults With Type 2 Diabetes
Canadian Journal of Diabetes. 45(5):411-416 [DOI] 10.1016/j.jcjd.2021.01.011. [PMID] 33722492.
2021
Real-World Screening for Retinopathy in Youth With Type 1 Diabetes Using a Nonmydriatic Fundus Camera
Diabetes Spectrum. 34(1):27-33 [DOI] 10.2337/ds20-0017. [PMID] 33627991.
2021
Substance Use Affects Type 1 Diabetes Pancreas Pathology: Implications for Future Studies.
Frontiers in endocrinology. 12 [DOI] 10.3389/fendo.2021.778912. [PMID] 34912300.
2020
A Novel Mutation in Insulin-Like Growth Factor 1 Receptor (c.641-2A>G) Is Associated with Impaired Growth, Hypoglycemia, and Modified Immune Phenotypes
Hormone Research in Paediatrics. 93(5):322-334 [DOI] 10.1159/000510764. [PMID] 33113547.
2020
Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes.
Diabetes technology & therapeutics. 22(12):948-953 [DOI] 10.1089/dia.2020.0305. [PMID] 32833543.
2020
Erratum. Who Is Enrolling? The Path to Monitoring in Type 1 Diabetes TrialNet’s Pathway to Prevention. Diabetes Care 2019;42:2228-2236.
Diabetes care. 43(4) [DOI] 10.2337/dc20-er04. [PMID] 32132004.
2020
Histological validation of a type 1 diabetes clinical diagnostic model for classification of diabetes.
Diabetic medicine : a journal of the British Diabetic Association. 37(12):2160-2168 [DOI] 10.1111/dme.14361. [PMID] 32634859.
2020
Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes
Diabetes Care. 43(1):5-12 [DOI] 10.2337/dc19-0880. [PMID] 31753960.
2020
The risk of progression to type 1 diabetes is highly variable in individuals with multiple autoantibodies following screening
Diabetologia. 63(3):588-596 [DOI] 10.1007/s00125-019-05047-w. [PMID] 31768570.
2019
Islet amyloidosis in a child with type 1 diabetes
Islets. 11(2):44-49 [DOI] 10.1080/19382014.2019.1599707. [PMID] 31084520.
2019
Predicting progression to type 1 diabetes from ages 3 to 6 in islet autoantibody positive TEDDY children
Pediatric Diabetes. 20(3):263-270 [DOI] 10.1111/pedi.12812. [PMID] 30628751.
2019
Who Is Enrolling? The Path to Monitoring in Type 1 Diabetes TrialNet’s Pathway to Prevention
Diabetes Care. 42(12):2228-2236 [DOI] 10.2337/dc19-0593. [PMID] 31558546.
2018
Immune Mechanisms and Pathways Targeted in Type 1 Diabetes.
Current diabetes reports. 18(10) [DOI] 10.1007/s11892-018-1066-5. [PMID] 30168021.
2018
Pancreatic Histopathology of Human Monogenic Diabetes Due to Causal Variants in KCNJ11, HNF1A, GATA6, and LMNA.
The Journal of clinical endocrinology and metabolism. 103(1):35-45 [DOI] 10.1210/jc.2017-01159. [PMID] 28938416.
2018
Presymptomatic screening for autoimmune β-cell disorder: Baby steps toward prevention?
Pediatric diabetes. 19(1):11-13 [DOI] 10.1111/pedi.12620. [PMID] 29368416.
2018
Understanding Pre-Type 1 Diabetes: The Key to Prevention.
Frontiers in endocrinology. 9 [DOI] 10.3389/fendo.2018.00070. [PMID] 29559955.
2017
High Illicit Drug Abuse and Suicide in Organ Donors With Type 1 Diabetes
Diabetes Care. 40(9):e122-e123 [DOI] 10.2337/dc17-0996.
2017
Insulin, insulin antibodies and insulin autoantibodies
.
2017
Insulin, insulin antibodies and insulin autoantibodies.
MLO: medical laboratory observer. 49(2):16-18 [PMID] 30005474.
2017
Poor Adherence to Ketone Testing in Patients With Type 1 Diabetes.
Diabetes care. 40(4):e38-e39 [DOI] 10.2337/dc16-2620. [PMID] 28100607.
2017
T Cell Receptor Profiling in Type 1 Diabetes.
Current diabetes reports. 17(11) [DOI] 10.1007/s11892-017-0946-4. [PMID] 29022222.
2017
Type 1 diabetes mellitus.
Nature reviews. Disease primers. 3 [DOI] 10.1038/nrdp.2017.16. [PMID] 28358037.
2016
Current and future efforts toward the prevention of type 1 diabetes.
Pediatric diabetes. 17 Suppl 22:78-86 [DOI] 10.1111/pedi.12333. [PMID] 27411441.
2016
Diagnostic Dilemma: Clinical and Histological Abnormalities in a Hispanic Patient With Diabetes.
Diabetes care. 39(9):1650-2 [DOI] 10.2337/dc16-0711. [PMID] 27555624.
2016
Presumptive Type 1 Diabetes With Comorbidities and Rapid Progression Despite Numerous Insulin-Positive Islets.
Diabetes care. 39(7):1292-4 [DOI] 10.2337/dc16-0737. [PMID] 27330131.
2016
Tablet/Capsule Size Variation Among The Most Commonly Prescribed Medications For Children In The Usa: Retrospective Review And Firsthand Pharmacy Audit.
Paediatric drugs. 18(1):65-73 [DOI] 10.1007/s40272-015-0156-y. [PMID] 26801779.
2015
A Pilot Study Of The Pediatric Oral Medications Screener (Poms).
Hospital pediatrics. 5(11):586-90 [DOI] 10.1542/hpeds.2015-0027. [PMID] 26526805.
2015
Effectiveness Of Pediatric Pill Swallowing Interventions: A Systematic Review.
Pediatrics. 135(5):883-9 [DOI] 10.1542/peds.2014-2114. [PMID] 25896843.
2015
Nail Findings In Hand-Foot-And-Mouth Disease.
The Pediatric infectious disease journal. 34(4):449-50 [DOI] 10.1097/INF.0000000000000574. [PMID] 25764101.
2010
Errors in the diagnosis and management of necrotizing otitis externa.
Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 143(4):506-9 [DOI] 10.1016/j.otohns.2010.06.924. [PMID] 20869559.
2010
Errors in the diagnosis and management of necrotizing otitis externa.
The Laryngoscope. 120 Suppl 4 [DOI] 10.1002/lary.21673. [PMID] 21225805.

Grants

Jun 2023 ACTIVE
Immune Function and the Progression to Type 1 Diabetes
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Jul 2021 ACTIVE
Development of a Predictive Response Signature to Anti-Thymocyte Globulin in Type 1 Diabetes
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Feb 2020 ACTIVE
TrialNet Clinical Center infrastructure support services
Role: Co-Investigator
Funding: UNIV OF SOUTH FLORIDA via NATL INST OF HLTH NIDDK
Nov 2019 – Sep 2021
A Phase 2 Multi-Center, Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Safety of TOL-3021 in Patients with New Onset or Established Type 1 Diabetes Mellitus
Role: Principal Investigator
Funding: EMMES via TOLERION
Aug 2019 – Mar 2024
Home Video-Based Telemedicine to Reduce Hypoglycemia Fear in Parents of Young Children (RedCHip)
Role: Co-Investigator
Funding: NEMOURS CHILDRENS CLINIC via NATL INST OF HLTH NIDDK
Jun 2019 – Mar 2024
Diabetes Journey: From systematic screening to intervention
Role: Co-Investigator
Funding: CINCINNATI CHILDRENS HOSPITAL MED CTR via NATL INST OF HLTH NIDDK
Oct 2018 – Sep 2022
T cell receptor sequencing in type 1 diabetes – biomarker discovery and technology development
Role: Co-Investigator
Funding: HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Jun 2018 – Jun 2019
Characterization of T cell Autoreactivity in Type 1 Diabetes
Role: Principal Investigator
Funding: BREAKTHROUGH T1D – formerly JDRF Intl
Jul 2017 – May 2018
PES Travel Grant
Role: Principal Investigator
Funding: PEDIATRIC ENDOCRINE SOCIETY via ELI LILLY AND CO
Apr 2016 – Feb 2021
The CD226 amd TIGIT costimulatory Axis in Type 1
Role: Project Manager
Funding: NATL INST OF HLTH NIDDK
Jun 2014 – Apr 2020
TrialNet: University of Florida Clinical Center and Network
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK

Education

Fellowship – Pediatric Endocrinology
2015-2018 · University of Florida
Residency – Pediatrics
2012-2015 · University of North Carolina
Medical School
2008-2012 · University of Florida

Contact Details

Phones:
Business:
(352) 265-7337
Emails:
Business:
lauraj@ufl.edu
Addresses:
Business Mailing:
PO Box 100296
GAINESVILLE FL 32610
Business Street:
1600 SW ARCHER RD
GAINESVILLE FL 32610