Laura Jacobsen, M.D.
Assistant Professor
About Laura Jacobsen
Hello, my name is Laura Jacobsen and I am an assistant professor and pediatric endocrinologist. I joined the University of Florida faculty in 2018 in the department of pediatrics. I was inspired to become a physician when I volunteered at the Florida Diabetes Camp and found my passion for caring for children with complex medical conditions.
I completed my pediatric residency training at the University of North Carolina in Chapel Hill, which was followed by a pediatric endocrinology fellowship at the UF Health Shands Children’s Hospital in Gainesville, Florida. During my fellowship, I was recognized for excellence in medical student teaching, and received the Henry A. Kokomoor Outstanding Fellowship Award.
I provide clinical care for children with endocrine disorders and diabetes. I perform clinical and translational research in the field of Type 1 diabetes to better understand what causes Type 1 diabetes and ways to halt or prevent it. I am also conversational in American Sign Language. I aim to improve the lives of children and their families living with diabetes and endocrine conditions, not just medically but in all aspects of day-to-day life. Additionally, I strive to bring new therapies and technologies to individuals with type 1 diabetes.
When I am not working I enjoy spending time crocheting, playing soccer and visiting National parks.
Accomplishments
Excellence in Medical Student Education Pediatric Clerkship Rotation
2019
·
UF Department of Pediatrics
Henry A. Kokomoor Outstanding Fellowship Award
2017
·
UF Department of Pediatrics
Type 1 Diabetes TrialNet Emerging Leader
2017
·
Type 1 Diabetes TrialNet
Floyd W. Denny Pediatric Society Resident Award for Excellence in Pediatric Care
2015
·
UNC Department of Pediatrics
Johnny Carson Award for Best Overall Research Evening of Scholarship
2015
·
UNC Department of Pediatrics
UF Chapman Chapter of the Gold Humanism Honor Society Inductee
2011
·
UF College of Medicine
Teaching Profile
Courses Taught
2018
MDC7400 Pediatric Clerkship
2018
MDT7090 Elective Topics
2018
MDC6001 Intro Clin Practice
Board Certifications
-
Pediatric EndocrinologyAmerican Board of Pediatrics
-
PediatricsAmerican Board of Pediatrics
Clinical Profile
Specialties
- Pediatrics
Subspecialties
- Pediatric Endocrinology
Areas of Interest
- Blood glucose monitoring
- Pediatric pituitary and skull base services
- Type 1 diabetes
- Type 2 diabetes
Research Profile
Areas of Interest
- Diabetes Technology
- Immunology of Type 1 diabetes
- Prevention and intervention trials in Type 1 diabetes
- Type 1 Diabetes
Open Researcher and Contributor ID (ORCID)
0000-0002-5144-7836
Publications
2024
Comparisons of Metabolic Measures to Predict T1D vs Detect a Preventive Treatment Effect in High-Risk Individuals.
The Journal of clinical endocrinology and metabolism.
109(8):2116-2123
[DOI] 10.1210/clinem/dgae048.
[PMID] 38267821.
2024
Consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes
Diabetologia.
67(9):1731-1759
[DOI] 10.1007/s00125-024-06205-5.
[PMID] 38910151.
2024
Consensus Guidance for Monitoring Individuals With Islet Autoantibody–Positive Pre-Stage 3 Type 1 Diabetes
Diabetes Care.
[DOI] 10.2337/dci24-0042.
[PMID] 38912694.
2024
Correction to: Consensus guidance for monitoring individuals with islet autoantibody‑positive pre‑stage 3 type 1 diabetes
Diabetologia.
67(9):2012-2014
[DOI] 10.1007/s00125-024-06266-6.
[PMID] 39230637.
2024
Early Metabolic Endpoints Identify Persistent Treatment Efficacy in Recent-Onset Type 1 Diabetes Immunotherapy Trials
Diabetes Care.
47(6):1048-1055
[DOI] 10.2337/dc24-0171.
[PMID] 38621411.
2024
Effect of Oral Insulin on Early Combined Glucose and C‐Peptide Endpoints in Individuals at High‐Risk for Type 1 Diabetes
Pediatric Diabetes.
2024(1)
[DOI] 10.1155/2024/8343868.
2024
Erratum. Consensus Guidance for Monitoring Individuals With Islet Autoantibody-Positive Pre-Stage 3 Type 1 Diabetes. Diabetes Care 2024;47:1276-1298.
Diabetes care.
[DOI] 10.2337/dc24-er11a.
[PMID] 39240700.
2024
Low-Dose Antithymocyte Globulin: A Pragmatic Approach to Treating Stage 2 Type 1 Diabetes
Diabetes Care.
47(2):285-289
[DOI] 10.2337/dc23-1750.
[PMID] 38117469.
2024
Prompt Recognition of New-Onset Type 1 Diabetes Is Everyone’s Responsibility—Even on Weekends
Diabetes Care.
47(4):646-648
[DOI] 10.2337/dci23-0096.
2023
Factors Associated With Achieving Target A1C in Children and Adolescents With Type 1 Diabetes: Findings From the T1D Exchange Quality Improvement Collaborative
Clinical Diabetes.
41(1):68-75
[DOI] 10.2337/cd22-0073.
[PMID] 36714245.
2023
Human immune phenotyping reveals accelerated aging in type 1 diabetes
JCI Insight.
8(17)
[DOI] 10.1172/jci.insight.170767.
[PMID] 37498686.
2023
Longitudinal Trends in Glycemic Outcomes and Technology Use for Over 48,000 People with Type 1 Diabetes (2016–2022) from the T1D Exchange Quality Improvement Collaborative
Diabetes Technology & Therapeutics.
25(11):765-773
[DOI] 10.1089/dia.2023.0320.
2023
Phenotypes Associated With Zones Defined by Area Under the Curve Glucose and C-peptide in a Population With Islet Autoantibodies
Diabetes Care.
46(5):1098-1105
[DOI] 10.2337/dc22-2236.
[PMID] 37000695.
2023
Responders to low-dose ATG induce CD4+ T cell exhaustion in type 1 diabetes
JCI Insight.
8(16)
[DOI] 10.1172/jci.insight.161812.
[PMID] 37432736.
2023
Type 1 Diabetes Continuous Glucose Monitoring Use in the Pediatric Emergency Department Affects Laboratory Test Frequency but Not Treatment Timing
Diabetes Spectrum.
36(3):275-280
[DOI] 10.2337/ds22-0061.
[PMID] 37583555.
2023
Utility and precision evidence of technology in the treatment of type 1 diabetes: a systematic review.
Communications medicine.
3(1)
[DOI] 10.1038/s43856-023-00358-x.
[PMID] 37794113.
2022
ISPAD
Clinical Practice Consensus Guidelines 2022: Stages of type 1 diabetes in children and adolescents
Pediatric Diabetes.
23(8):1175-1187
[DOI] 10.1111/pedi.13410.
2022
Accuracy of Three Commercial Home-Use Hemoglobin A1c Tests
Diabetes Technology & Therapeutics.
24(11):789-796
[DOI] 10.1089/dia.2022.0187.
2022
Age and Hospitalization Risk in People With Type 1 Diabetes and COVID-19: Data From the T1D Exchange Surveillance Study.
The Journal of clinical endocrinology and metabolism.
107(2):410-418
[DOI] 10.1210/clinem/dgab668.
[PMID] 34581790.
2022
Cost-Effectiveness of Low-Dose Antithymocyte Globulin Versus Other Immunotherapies for Treatment of New-Onset Type 1 Diabetes
Diabetes Technology & Therapeutics.
24(4):258-267
[DOI] 10.1089/dia.2021.0329.
2022
Heterogeneity of DKA Incidence and Age-Specific Clinical Characteristics in Children Diagnosed With Type 1 Diabetes in the TEDDY Study
Diabetes Care.
45(3):624-633
[DOI] 10.2337/dc21-0422.
[PMID] 35043162.
2022
Hybrid Closed-Loop Systems and Glycemic Outcomes in Children and Adults With Type 1 Diabetes: Real-World Evidence From a U.S.-Based Multicenter Collaborative.
Diabetes care.
45(8):e118-e119
[DOI] 10.2337/dc22-0329.
[PMID] 35708494.
2022
Index60 Identifies Individuals at Appreciable Risk for Stage 3 Among an Autoantibody-Positive Population With Normal 2-Hour Glucose Levels: Implications for Current Staging Criteria of Type 1 Diabetes.
Diabetes care.
45(2):311-318
[DOI] 10.2337/dc21-0944.
[PMID] 34853027.
2022
Index60 Is Superior to HbA1c for Identifying Individuals at High Risk for Type 1 Diabetes
The Journal of Clinical Endocrinology & Metabolism.
107(10):2784-2792
[DOI] 10.1210/clinem/dgac440.
[PMID] 35880956.
2022
Learning experience design of an mHealth self-management intervention for adolescents with type 1 diabetes.
Educational technology research and development : ETR & D.
70(6):2171-2209
[DOI] 10.1007/s11423-022-10160-6.
[PMID] 36278247.
2022
Making Diabetes Electronic Medical Record Data Actionable: Promoting Benchmarking and Population Health Improvement Using the T1D Exchange Quality Improvement Portal.
Clinical diabetes : a publication of the American Diabetes Association.
41(1):45-55
[DOI] 10.2337/cd22-0072.
[PMID] 36714251.
2022
Persistence of β-Cell Responsiveness for Over Two Years in Autoantibody-Positive Children With Marked Metabolic Impairment at Screening.
Diabetes care.
45(12):2982-2990
[DOI] 10.2337/dc22-1362.
[PMID] 36326757.
2021
A retrospective multisite examination of depression screening practices, scores, and correlates in pediatric diabetes care.
Translational behavioral medicine.
11(1):122-131
[DOI] 10.1093/tbm/ibz171.
[PMID] 31764981.
2021
Adherence to oral glucose tolerance testing in children in stage 1 of type 1 diabetes: The
TEDDY
study
Pediatric Diabetes.
22(2):360-368
[DOI] 10.1111/pedi.13149.
[PMID] 33179853.
2021
Barriers to retinopathy screening in youth and young adults with type 1 diabetes
Pediatric Diabetes.
22(3):469-473
[DOI] 10.1111/pedi.13171.
2021
How Do We Move Type 1 Diabetes Immunotherapies Forward During the Current COVID-19 Pandemic?
Diabetes.
70(5):1021-1028
[DOI] 10.2337/dbi20-0045.
[PMID] 33632743.
2021
Index60 as an additional diagnostic criterion for type 1 diabetes.
Diabetologia.
64(4):836-844
[DOI] 10.1007/s00125-020-05365-4.
[PMID] 33496819.
2021
Insulin immunotherapy for pretype 1 diabetes.
Current opinion in endocrinology, diabetes, and obesity.
28(4):390-396
[DOI] 10.1097/MED.0000000000000648.
[PMID] 34091488.
2021
Low-Dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report
Diabetes.
70(5):1123-1129
[DOI] 10.2337/db20-1103.
[PMID] 33632742.
2021
Monogenic Diabetes and Integrated Stress Response Genes Display Altered Gene Expression in Type 1 Diabetes
Diabetes.
70(8):1885-1897
[DOI] 10.2337/db21-0070.
[PMID] 34035041.
2021
Multisite Examination of Depression Screening Scores and Correlates Among Adolescents and Young Adults With Type 2 Diabetes
Canadian Journal of Diabetes.
45(5):411-416
[DOI] 10.1016/j.jcjd.2021.01.011.
[PMID] 33722492.
2021
Real-World Screening for Retinopathy in Youth With Type 1 Diabetes Using a Nonmydriatic Fundus Camera
Diabetes Spectrum.
34(1):27-33
[DOI] 10.2337/ds20-0017.
[PMID] 33627991.
2021
Substance Use Affects Type 1 Diabetes Pancreas Pathology: Implications for Future Studies.
Frontiers in endocrinology.
12
[DOI] 10.3389/fendo.2021.778912.
[PMID] 34912300.
2020
A Novel Mutation in Insulin-Like Growth Factor 1 Receptor (c.641-2A>G) Is Associated with Impaired Growth, Hypoglycemia, and Modified Immune Phenotypes
Hormone Research in Paediatrics.
93(5):322-334
[DOI] 10.1159/000510764.
[PMID] 33113547.
2020
Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes.
Diabetes technology & therapeutics.
22(12):948-953
[DOI] 10.1089/dia.2020.0305.
[PMID] 32833543.
2020
Erratum. Who Is Enrolling? The Path to Monitoring in Type 1 Diabetes TrialNet’s Pathway to Prevention. Diabetes Care 2019;42:2228-2236.
Diabetes care.
43(4)
[DOI] 10.2337/dc20-er04.
[PMID] 32132004.
2020
Histological validation of a type 1 diabetes clinical diagnostic model for classification of diabetes.
Diabetic medicine : a journal of the British Diabetic Association.
37(12):2160-2168
[DOI] 10.1111/dme.14361.
[PMID] 32634859.
2020
Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes
Diabetes Care.
43(1):5-12
[DOI] 10.2337/dc19-0880.
[PMID] 31753960.
2020
The risk of progression to type 1 diabetes is highly variable in individuals with multiple autoantibodies following screening
Diabetologia.
63(3):588-596
[DOI] 10.1007/s00125-019-05047-w.
[PMID] 31768570.
2019
Islet amyloidosis in a child with type 1 diabetes
Islets.
11(2):44-49
[DOI] 10.1080/19382014.2019.1599707.
[PMID] 31084520.
2019
Predicting progression to type 1 diabetes from ages 3 to 6 in islet autoantibody positive TEDDY children
Pediatric Diabetes.
20(3):263-270
[DOI] 10.1111/pedi.12812.
[PMID] 30628751.
2019
Who Is Enrolling? The Path to Monitoring in Type 1 Diabetes TrialNet’s Pathway to Prevention
Diabetes Care.
42(12):2228-2236
[DOI] 10.2337/dc19-0593.
[PMID] 31558546.
2018
Immune Mechanisms and Pathways Targeted in Type 1 Diabetes.
Current diabetes reports.
18(10)
[DOI] 10.1007/s11892-018-1066-5.
[PMID] 30168021.
2018
Pancreatic Histopathology of Human Monogenic Diabetes Due to Causal Variants in KCNJ11, HNF1A, GATA6, and LMNA.
The Journal of clinical endocrinology and metabolism.
103(1):35-45
[DOI] 10.1210/jc.2017-01159.
[PMID] 28938416.
2018
Presymptomatic screening for autoimmune β-cell disorder: Baby steps toward prevention?
Pediatric diabetes.
19(1):11-13
[DOI] 10.1111/pedi.12620.
[PMID] 29368416.
2018
Understanding Pre-Type 1 Diabetes: The Key to Prevention.
Frontiers in endocrinology.
9
[DOI] 10.3389/fendo.2018.00070.
[PMID] 29559955.
2017
High Illicit Drug Abuse and Suicide in Organ Donors With Type 1 Diabetes
Diabetes Care.
40(9):e122-e123
[DOI] 10.2337/dc17-0996.
2017
Insulin, insulin antibodies and insulin autoantibodies
.
2017
Insulin, insulin antibodies and insulin autoantibodies.
MLO: medical laboratory observer.
49(2):16-18
[PMID] 30005474.
2017
Poor Adherence to Ketone Testing in Patients With Type 1 Diabetes.
Diabetes care.
40(4):e38-e39
[DOI] 10.2337/dc16-2620.
[PMID] 28100607.
2017
T Cell Receptor Profiling in Type 1 Diabetes.
Current diabetes reports.
17(11)
[DOI] 10.1007/s11892-017-0946-4.
[PMID] 29022222.
2017
Type 1 diabetes mellitus.
Nature reviews. Disease primers.
3
[DOI] 10.1038/nrdp.2017.16.
[PMID] 28358037.
2016
Current and future efforts toward the prevention of type 1 diabetes.
Pediatric diabetes.
17 Suppl 22:78-86
[DOI] 10.1111/pedi.12333.
[PMID] 27411441.
2016
Diagnostic Dilemma: Clinical and Histological Abnormalities in a Hispanic Patient With Diabetes.
Diabetes care.
39(9):1650-2
[DOI] 10.2337/dc16-0711.
[PMID] 27555624.
2016
Presumptive Type 1 Diabetes With Comorbidities and Rapid Progression Despite Numerous Insulin-Positive Islets.
Diabetes care.
39(7):1292-4
[DOI] 10.2337/dc16-0737.
[PMID] 27330131.
2016
Tablet/Capsule Size Variation Among The Most Commonly Prescribed Medications For Children In The Usa: Retrospective Review And Firsthand Pharmacy Audit.
Paediatric drugs.
18(1):65-73
[DOI] 10.1007/s40272-015-0156-y.
[PMID] 26801779.
2015
A Pilot Study Of The Pediatric Oral Medications Screener (Poms).
Hospital pediatrics.
5(11):586-90
[DOI] 10.1542/hpeds.2015-0027.
[PMID] 26526805.
2015
Effectiveness Of Pediatric Pill Swallowing Interventions: A Systematic Review.
Pediatrics.
135(5):883-9
[DOI] 10.1542/peds.2014-2114.
[PMID] 25896843.
2015
Nail Findings In Hand-Foot-And-Mouth Disease.
The Pediatric infectious disease journal.
34(4):449-50
[DOI] 10.1097/INF.0000000000000574.
[PMID] 25764101.
2010
Errors in the diagnosis and management of necrotizing otitis externa.
Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.
143(4):506-9
[DOI] 10.1016/j.otohns.2010.06.924.
[PMID] 20869559.
2010
Errors in the diagnosis and management of necrotizing otitis externa.
The Laryngoscope.
120 Suppl 4
[DOI] 10.1002/lary.21673.
[PMID] 21225805.
Grants
Sep 2024
ACTIVE
Restoration of immune regulation in type 1 diabetes through the synergistic action of insulin-like growth factor-1 and interleukin-2
Role: Co-Investigator
Funding: BREAKTHROUGH T1D – formerly JDRF Intl
Jun 2023
ACTIVE
Immune Function and the Progression to Type 1 Diabetes
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Jul 2021
ACTIVE
Development of a Predictive Response Signature to Anti-Thymocyte Globulin in Type 1 Diabetes
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Feb 2020
ACTIVE
TrialNet Clinical Center infrastructure support services
Role: Co-Investigator
Funding: UNIV OF SOUTH FLORIDA
via NATL INST OF HLTH NIDDK
Nov 2019
– Sep 2021
A Phase 2 Multi-Center, Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Safety of TOL-3021 in Patients with New Onset or Established Type 1 Diabetes Mellitus
Role: Principal Investigator
Funding: EMMES
via TOLERION
Aug 2019
ACTIVE
Home Video-Based Telemedicine to Reduce Hypoglycemia Fear in Parents of Young Children (RedCHip)
Role: Co-Investigator
Funding: NEMOURS CHILDRENS CLINIC
via NATL INST OF HLTH NIDDK
Jun 2019
– Mar 2024
Diabetes Journey: From systematic screening to intervention
Role: Co-Investigator
Funding: CINCINNATI CHILDRENS HOSPITAL MED CTR
via NATL INST OF HLTH NIDDK
Oct 2018
– Sep 2022
T cell receptor sequencing in type 1 diabetes – biomarker discovery and technology development
Role: Co-Investigator
Funding: HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Jun 2018
– Jun 2019
Characterization of T cell Autoreactivity in Type 1 Diabetes
Role: Principal Investigator
Funding: BREAKTHROUGH T1D – formerly JDRF Intl
Jul 2017
– May 2018
PES Travel Grant
Role: Principal Investigator
Funding: PEDIATRIC ENDOCRINE SOCIETY
via ELI LILLY AND CO
Apr 2016
– Feb 2021
The CD226 amd TIGIT costimulatory Axis in Type 1
Role: Project Manager
Funding: NATL INST OF HLTH NIDDK
Jun 2014
– Apr 2020
TrialNet: University of Florida Clinical Center and Network
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Education
Fellowship – Pediatric Endocrinology
2015-2018
·
University of Florida
Residency – Pediatrics
2012-2015
·
University of North Carolina
Medical School
2008-2012
·
University of Florida
Contact Details
Phones:
- Business:
- (352) 265-7337
Emails:
- Business:
- lauraj@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100296
GAINESVILLE FL 32610 - Business Street:
-
1600 SW ARCHER RD
GAINESVILLE FL 32610