Jennifer L Miller

Jennifer L Miller, M.D.

Professor

Department: MD-PEDS-ENDOCRINOLOGY
Business Phone: (352) 265-7337
Business Email: jlmiller@ufl.edu

About Jennifer L Miller

Dr. Miller is a Professor in the division of pediatric endocrinology. She graduated with her M.D. from the University of Florida in 1998, and her M.S. in Clinical Investigation from the University of Florida in 2005. She has done all of her training in pediatrics and pediatric endocrinology at the University of Florida. She specializes in the care and treatment of individuals with Prader-Willi syndrome and other genetic causes of early-onset excessive weight gain.

Accomplishments

Castle Connolly Regional Top Doctors
2018 · peer nomination, extensive research and careful review and screening by our doctor-directed research team
Customeer Service Key Award
2017 · Shands Hospital
Customer Service Key Award
2016 · Shands Hospital
Patient's Choice Award
2014-2018 · National Award
Compassionate Doctor Award
2011-2018 · National Award

Clinical Profile

Specialties
  • Pediatrics
Subspecialties
  • Pediatric Endocrinology
Areas of Interest
  • Diabetes
  • Diabetes – resources
  • High blood pressure – children
  • Obesity in children
  • Pediatric pituitary and skull base services
  • Prader-Willi syndrome

Research Profile

My research focuses on investigation of the etiology and possible treatment for obesity and metabolic abnormalities in individuals with Prader-Willi syndrome and early-onset obesity. I have been working towards achieving an appropriate treatment for hyperphagia for the past 12 years. I currently follow over 500 patients with Prader-Willi syndrome from around the world, and over 100 patients with early-onset obesity due to other genetic causes. I am working on clinical treatment trials to treat hyperphagia in individuals with Prader-Willi syndrome and early-onset obesity..

Publications

2021
Adults with Prader-Willi syndrome exhibit a unique microbiota profile.
BMC research notes. 14(1) [DOI] 10.1186/s13104-021-05470-6. [PMID] 33549146.
2021
Evaluating Sleep Disturbances in Children With Rare Genetic Neurodevelopmental Syndromes.
Pediatric neurology. 123:30-37 [DOI] 10.1016/j.pediatrneurol.2021.07.009. [PMID] 34388423.
2021
Hypogonadism in Adult Males with Prader-Willi Syndrome-Clinical Recommendations Based on a Dutch Cohort Study, Review of the Literature and an International Expert Panel Discussion.
Journal of clinical medicine. 10(19) [DOI] 10.3390/jcm10194361. [PMID] 34640379.
2021
Incidence of strabismus, strabismus surgeries, and other vision conditions in Prader-Willi syndrome: data from the Global Prader-Willi Syndrome Registry.
BMC ophthalmology. 21(1) [DOI] 10.1186/s12886-021-02057-4. [PMID] 34380467.
2021
Influence of molecular classes and growth hormone treatment on growth and dysmorphology in Prader-Willi syndrome: A multicenter study.
Clinical genetics. 100(1):29-39 [DOI] 10.1111/cge.13947. [PMID] 33615449.
2020
Dietary Management for Adolescents with Prader-Willi Syndrome.
Adolescent health, medicine and therapeutics. 11:113-118 [DOI] 10.2147/AHMT.S214893. [PMID] 32922110.
2020
Microbiota profile and efficacy of probiotic supplementation on laxation in adults affected by Prader-Willi Syndrome: A randomized, double-blind, crossover trial.
Molecular genetics & genomic medicine. 8(12) [DOI] 10.1002/mgg3.1535. [PMID] 33103385.
2019
A multidisciplinary approach to the clinical management of Prader-Willi syndrome.
Molecular genetics & genomic medicine. 7(3) [DOI] 10.1002/mgg3.514. [PMID] 30697974.
2019
Birth seasonality studies in a large Prader-Willi syndrome cohort.
American journal of medical genetics. Part A. 179(8):1531-1534 [DOI] 10.1002/ajmg.a.61263. [PMID] 31225937.
2019
Early Diagnosis in Prader-Willi Syndrome Reduces Obesity and Associated Co-Morbidities.
Genes. 10(11) [DOI] 10.3390/genes10110898. [PMID] 31698873.
2019
Molecular genetic classification in Prader-Willi syndrome: a multisite cohort study.
Journal of medical genetics. 56(3):149-153 [DOI] 10.1136/jmedgenet-2018-105301. [PMID] 29730598.
2019
Prader-Willi Syndrome – Clinical Genetics, Diagnosis and Treatment Approaches: An Update.
Current pediatric reviews. 15(4):207-244 [DOI] 10.2174/1573396315666190716120925. [PMID] 31333129.
2018
Hormonal, metabolic and skeletal phenotype of Schaaf-Yang syndrome: a comparison to Prader-Willi syndrome.
Journal of medical genetics. 55(5):307-315 [DOI] 10.1136/jmedgenet-2017-105024. [PMID] 29496979.
2018
Multicentre study of maternal and neonatal outcomes in individuals with Prader-Willi syndrome.
Journal of medical genetics. 55(9):594-598 [DOI] 10.1136/jmedgenet-2017-105118. [PMID] 29776967.
2018
Oxytocin and Naltrexone Successfully Treat Hypothalamic Obesity in a Boy Post-Craniopharyngioma Resection.
The Journal of clinical endocrinology and metabolism. 103(2):370-375 [DOI] 10.1210/jc.2017-02080. [PMID] 29220529.
2018
The effects of Bifidobacterium animalis ssp. lactis B94 on gastrointestinal wellness in adults with Prader-Willi syndrome: study protocol for a randomized controlled trial.
Trials. 19(1) [DOI] 10.1186/s13063-018-2648-x. [PMID] 29703235.
2017
Oxytocin treatment in children with Prader-Willi syndrome: A double-blind, placebo-controlled, crossover study.
American journal of medical genetics. Part A. 173(5):1243-1250 [DOI] 10.1002/ajmg.a.38160. [PMID] 28371242.
2016
Elevated plasma oxytocin levels in children with Prader-Willi syndrome compared with healthy unrelated siblings.
American journal of medical genetics. Part A. 170(3):594-601 [DOI] 10.1002/ajmg.a.37488. [PMID] 26615966.
2016
Growth Charts for Prader-Willi Syndrome During Growth Hormone Treatment.
Clinical pediatrics. 55(10):957-74 [DOI] 10.1177/0009922815617973. [PMID] 26842920.
2016
Higher plasma orexin a levels in children with Prader-Willi syndrome compared with healthy unrelated sibling controls.
American journal of medical genetics. Part A. 170(9):2328-33 [DOI] 10.1002/ajmg.a.37777. [PMID] 27518917.
2016
Higher plasma orexin A levels in children with Prader-Willi syndrome compared with healthy unrelated sibling controls.
American journal of medical genetics. Part A. 170(8):2097-102 [DOI] 10.1002/ajmg.a.37749. [PMID] 27214028.
2016
The High Direct Medical Costs of Prader-Willi Syndrome.
The Journal of pediatrics. 175:137-43 [DOI] 10.1016/j.jpeds.2016.05.018. [PMID] 27283463.
2015
Growth charts for non-growth hormone treated Prader-Willi syndrome.
Pediatrics. 135(1):e126-35 [DOI] 10.1542/peds.2014-1711. [PMID] 25489013.
2015
Hyperghrelinemia in Prader-Willi syndrome begins in early infancy long before the onset of hyperphagia.
American journal of medical genetics. Part A. 167A(1):69-79 [DOI] 10.1002/ajmg.a.36810. [PMID] 25355237.
2015
Laparoscopic sleeve gastrectomy in 108 obese children and adolescents ages 5 to 21 years by Alqahtani AR, Antonisamy B, Alamri H, Elahmedi M, Zimmerman VA.
Annals of surgery. 261(4) [DOI] 10.1097/SLA.0b013e3182a7187c. [PMID] 24045441.
2015
Medication Trials for Hyperphagia and Food-Related Behaviors in Prader-Willi Syndrome.
Diseases (Basel, Switzerland). 3(2):78-85 [DOI] 10.3390/diseases3020078. [PMID] 28943610.
2015
The neurobiological drive for overeating implicated in Prader-Willi syndrome.
Brain research. 1620:72-80 [DOI] 10.1016/j.brainres.2015.05.008. [PMID] 25998539.
2014
An open-label pilot study of N-acetylcysteine for skin-picking in Prader-Willi syndrome.
American journal of medical genetics. Part A. 164A(2):421-4 [DOI] 10.1002/ajmg.a.36306. [PMID] 24311388.
2014
Effects of metformin in children and adolescents with Prader-Willi syndrome and early-onset morbid obesity: a pilot study.
Journal of pediatric endocrinology & metabolism : JPEM. 27(1-2):23-9 [DOI] 10.1515/jpem-2013-0116. [PMID] 23893676.
2014
Frequency of Prader-Willi syndrome in births conceived via assisted reproductive technology.
Genetics in medicine : official journal of the American College of Medical Genetics. 16(2):164-9 [DOI] 10.1038/gim.2013.97. [PMID] 23928912.
2014
Hypoglycemia in Prader-Willi syndrome.
American journal of medical genetics. Part A. 164A(5):1127-9 [DOI] 10.1002/ajmg.a.36405. [PMID] 24458695.
2014
Morbidity of total pancreatectomy with islet cell auto-transplantation compared to total pancreatectomy alone.
HPB : the official journal of the International Hepato Pancreato Biliary Association. 16(6):522-7 [DOI] 10.1111/hpb.12168. [PMID] 23992021.
2014
Perioperative outcomes of pancreaticoduodenectomy compared to total pancreatectomy for neoplasia.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 18(3):549-54 [DOI] 10.1007/s11605-013-2393-0. [PMID] 24165872.
2013
Altered functional brain networks in Prader-Willi syndrome.
NMR in biomedicine. 26(6):622-9 [DOI] 10.1002/nbm.2900. [PMID] 23335390.
2013
Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi-like features.
The Journal of clinical investigation. 123(7):3037-41 [DOI] 10.1172/JCI68035. [PMID] 23778136.
2013
Prader-Willi Syndrome and Sleep-Disordered Breathing
Pediatric Annals. 42(10):200-204 [DOI] 10.3928/00904481-20130924-10. [PMID] 24126982.
2012
Approach to the child with prader-willi syndrome.
The Journal of clinical endocrinology and metabolism. 97(11):3837-44 [DOI] 10.1210/jc.2012-2543. [PMID] 23129592.
2012
Letter to the editor: Long-term experience with duodenal switch in adolescents.
Obesity surgery. 22(3):517-8 [DOI] 10.1007/s11695-011-0502-2. [PMID] 21874367.
2012
Prader-Willi syndrome.
Genetics in medicine : official journal of the American College of Medical Genetics. 14(1):10-26 [DOI] 10.1038/gim.0b013e31822bead0. [PMID] 22237428.
2012
Unique and atypical deletions in Prader-Willi syndrome reveal distinct phenotypes.
European journal of human genetics : EJHG. 20(3):283-90 [DOI] 10.1038/ejhg.2011.187. [PMID] 22045295.
2011
Carnitine and coenzyme Q10 levels in individuals with Prader-Willi syndrome.
American journal of medical genetics. Part A. 155A(3):569-73 [DOI] 10.1002/ajmg.a.33887. [PMID] 21337696.
2011
Nutritional phases in Prader-Willi syndrome.
American journal of medical genetics. Part A. 155A(5):1040-9 [DOI] 10.1002/ajmg.a.33951. [PMID] 21465655.
2009
“Efficacy of laparoscopic sleeve gastrectomy as a stand-alone technique for children with morbid obesity” and “BioEnterics intragastric balloon for treatment of morbid obesity in Prader-Willi syndrome: specific risks and benefits”.
Obesity surgery. 19(5):671-2; author reply 673 [DOI] 10.1007/s11695-008-9742-1. [PMID] 18982398.
2009
Early childhood obesity is associated with compromised cerebellar development.
Developmental neuropsychology. 34(3):272-83 [DOI] 10.1080/87565640802530961. [PMID] 19437203.
2009
Sleep disordered breathing in infants with Prader-Willi syndrome during the first 6 weeks of growth hormone therapy: a pilot study.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine. 5(5):448-53 [PMID] 19961030.
View on: PubMed
2009
Sleep disordered breathing in infants with Prader-Willi syndrome during the first 6 weeks of growth hormone therapy: a pilot study.
Journal of Clinical Sleep Medicine. 5(5) [PMID] 19961030.
View on: PubMed
2008
Pituitary abnormalities in Prader-Willi syndrome and early onset morbid obesity.
American journal of medical genetics. Part A. 146A(5):570-7 [PMID] 17431897.
View on: PubMed
2008
Potency and fate specification in CNS stem cell populations in vitro.
Cell stem cell. 3(6):670-80 [DOI] 10.1016/j.stem.2008.09.012. [PMID] 19041783.
2007
Enhanced activation of reward mediating prefrontal regions in response to food stimuli in Prader-Willi syndrome.
Journal of neurology, neurosurgery, and psychiatry. 78(6):615-9 [PMID] 17158560.
View on: PubMed
2007
Intracranial abnormalities detected by three-dimensional magnetic resonance imaging in Prader-Willi syndrome.
American journal of medical genetics. Part A. 143A(5):476-83 [PMID] 17103438.
View on: PubMed
2007
Management approaches for pediatric obesity.
Nature clinical practice. Endocrinology & metabolism. 3(12):810-8 [PMID] 18026159.
View on: PubMed
2007
Sylvian fissure morphology in Prader-Willi syndrome and early-onset morbid obesity.
Genetics in medicine : official journal of the American College of Medical Genetics. 9(8):536-43 [PMID] 17700392.
View on: PubMed
2006
Central hypothyroidism with oxcarbazepine therapy.
Pediatric neurology. 34(3):242-4 [PMID] 16504798.
View on: PubMed
2006
Short-term effects of growth hormone on sleep abnormalities in Prader-Willi syndrome.
The Journal of clinical endocrinology and metabolism. 91(2):413-7 [PMID] 16317059.
View on: PubMed
2006
The treatment of type 2 diabetes mellitus in youth : which therapies?
Treatments in endocrinology. 5(4):201-10 [PMID] 16878999.
View on: PubMed
2005
The management of type 2 diabetes mellitus in children and adolescents.
Journal of pediatric endocrinology & metabolism : JPEM. 18(2):111-23 [PMID] 15751600.
View on: PubMed

Grants

Apr 2019 – Mar 2020
PATH for PWS – PATH Study Investigator
Role: Principal Investigator
Funding: FOU FOR PRADER-WILLI RESEARCH
Jun 2017 – May 2019
Evaluating Factors that may affect the Efficacy of Intranasal Oxytocin Treatment in PWS
Role: Principal Investigator
Funding: FOU FOR PRADER-WILLI RESEARCH
Jun 2017 – May 2019
Phase 2 Study: Intranasal Oxytocin for Treatment of Infants and Children with Prader-Willi Syndrome in Nutritional Phase 1a
Role: Principal Investigator
Funding: PRADER-WILLI SYNDROME ASSO
Jul 2015 – Jun 2020
Prader-Willi Syndrome Research Fund
Role: Principal Investigator
Funding: UF FOU
Feb 2015 – Dec 2020
T+?a Marie DeFelice Prader-Willi Syndrome Research Fund
Role: Principal Investigator
Funding: UF FOU
Dec 2014 – Dec 2017
Randomized, Double-Blind, Pacebo-Controlled, Phase 3 Trial of ZGN-440 (Subcutaneous Beloranib in Suspension) in Obese Subjects with Prader-Willi Syndrome to Evaluate Total Body Fat Mass, Food-related Behavior and Safety over 6 Months
Role: Principal Investigator
Funding: ZAFGEN
Nov 2014 – Nov 2017
A Phase 2 Randomized Double-Blind Placebo-controlled Pilot Study to Assess the Effects of RM-493 a Melanocortin 4 Receptor (MC4R) Agonist in Obese Subjects with Prader-Willi Syndrome (PWS) on Safety Weight Reduction and Food-Related Behaviors
Role: Principal Investigator
Funding: RHYTHM PHARMACEUTICALS
Nov 2014 – Nov 2017
A Phase 2, Randomized, Double-Blind Placebo-controlled Pilot Study to Assess the Effects of RM-493, a Melanocortin 4 Receptor Agonist in Obese Subjects with Prader-Willi Syndrome on Safety, Weight Reduction, and Food-Related Behaviors
Role: Principal Investigator
Funding: RHYTHM PHARMACEUTICALS

Education

Master of Clinical Investigation
2003-2005 · University of Florida
Pediatric Endocrinology Fellowship
2001-2004 · University of Florida
Pediatric Residency
1998-2001 · University of Florida
Medical Doctor
1994-1998 · University of Florida
Bachelor of Science
1990-1994 · Emory University
Master of Science
1990-1994 · Emory University

Teaching Profile

Courses Taught
2018
MDC7400 Pediatric Clerkship

Contact Details

Phones:
Business:
(352) 265-7337
Emails:
Business:
jlmiller@ufl.edu