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Division of Endocrinology

Department of Pediatrics in the College of Medicine

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Michael J Haller

Michael J Haller, M.D.

Professor And Chief

Department: MD-PEDS-ENDOCRINOLOGY
Business Phone: (352) 273-9264
Business Email: hallerms@ufl.edu
CV: View Curriculum Vitae

About Michael J Haller

Dr. Haller is Professor and Chief of Pediatric Endocrinology at the University of Florida. He has been involved in type 1 diabetes research since the early 1990s and has published over 200 manuscripts and more than 20 reviews/book chapters on type 1 diabetes pathogenesis, prevention, and interdiction. He is the principal investigator or co-investigator on numerous JDRF, NIH, and Helmsley trust funded studies.

Honors & Awards

2017-2020 · University of Florida
2016 · University of Florida
2010 · ISPAD
2009 · ADA
2008 · Society for Pediatric Research
2008 · JDRF
2007 · JDRF
2005 · University of Florida
2004 · University of Florida

Board Certifications

  • Pediatric Endocrinology
    American Board of Pediatrics
  • Pediatrics
    American Board of Pediatrics

Clinical Profile

Specialties
  • Pediatrics
Subspecialties
  • Pediatric Endocrinology
Areas of Interest
  • Type 1 diabetes

Research Profile

Dr. Haller’s research focuses on predicting, preventing, and ultimately reversing type 1 diabetes through his participation in numerous clinical trials utilizing immunotherapies. Dr. Haller serves as the Principal Investigator for the University of Florida TrialNet Clinical Center, Chair of the TEDDY Clinical Implementation Committee, and PI of the UF/Stanford ECHO Collaborative. Dr. Haller also leads and participates in technology studies seeking to improve the lives of people living with diabetes through the use of pumps, continuous glucose monitors, and systems that automate insulin delivery.

Areas of Interest
  • Prevention and intervention trials in Type 1 diabetes
  • Type 1 Diabetes Treatment

Publications

2020
Clinical trial data validate the C-peptide estimate model in type 1 diabetes
Diabetologia
2020
Human Regulatory T Cells From Umbilical Cord Blood Display Increased Repertoire Diversity and Lineage Stability Relative to Adult Peripheral Blood
Frontiers in Immunology
2020
Commercially Available Insulin Products Demonstrate Stability Throughout the Cold Supply Chain Across the United States
Diabetes Care
2019
Estimated Lifetime Economic Burden of Type 1 Diabetes
Diabetes Technology & Therapeutics
2019
Biologic and social factors predict incident kidney disease in type 1 diabetes: Results from the T1D exchange clinic network
Journal of Diabetes and Its Complications
2018
Family Adjustment to Diabetes Diagnosis in Children: Can Participation in a Study on Type 1 Diabetes Genetic Risk Be Helpful?
2018
Immune Mechanisms and Pathways Targeted in Type 1 Diabetes.
Current Diabetes Reports
2018
Ispad Clinical Practice Consensus Guidelines 2018: Stages of Type 1 Diabetes in Children and Adolescents
Pediatric Diabetes
2018
Low-Dose Anti-Thymocyte Globulin (Atg) Preserves -Cell Function and Improves Hba(1C) in New-Onset Type 1 Diabetes
Diabetes Care
2018
Objectively Measured Adherence in Adolescents With Type 1 Diabetes on Multiple Daily Injections and Insulin Pump Therapy.
Journal of Pediatric Psychology
2018
Pandemrix (R) Vaccination Is Not Associated With Increased Risk of Islet Autoimmunity or Type 1 Diabetes in the Teddy Study Children
2017
Analgesic Antipyretic Use Among Young Children in the Teddy Study: No Association With Islet Autoimmunity
Bmc Pediatrics
2017
Expansion of Human Tregs From Cryopreserved Umbilical Cord Blood for Gmp-Compliant Autologous Adoptive Cell Transfer Therapy
2017
Lactobacillus Johnsonii N6.2 Modulates the Host Immune Responses: a Double-Blind, Randomized Trial in Healthy Adults
Frontiers in Immunology
2017
Rebranding Asymptomatic Type 1 Diabetes: the Case for Autoimmune Beta Cell Disorder As a Pathological and Diagnostic Entity
2016
The Influence of Type 1 Diabetes on Pancreatic Weight
2016
Mobilization Without Immune Depletion Fails to Restore Immunological Tolerance or Preserve Beta Cell Function in Recent Onset Type 1 Diabetes
Clinical and Experimental Immunology
2016
Updates on Immune Therapies in Type 1 Diabetes.
European endocrinology
2016
Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: the Environmental Determinants of Diabetes in the Young Study
Diabetes
2016
Identification of Tissue-Specific Cell Death Using Methylation Patterns of Circulating DNa
Proceedings of the National Academy of Sciences of the United States of America
2015
Prevalence of Detectable C-Peptide According To Age At Diagnosis and Duration of Type 1 Diabetes
Diabetes Care
2015
Anti-Thymocyte Globulin/G-Csf Treatment Preserves Beta Cell Function in Patients With Established Type 1 Diabetes
Journal of Clinical Investigation
2015
Screening for T1D Risk to Reduce Dka Is Not Economically Viable
2014
A Contrast Between Children and Adolescents With Excellent and Poor Control: the T1D Exchange Clinic Registry Experience
2014
Children Followed in the Teddy Study Are Diagnosed With Type 1 Diabetes At An Early Stage of Disease
2014
Effect of a Single Autologous Cord Blood Infusion On Beta-Cell and Immune Function in Children With New Onset Type 1 Diabetes: a Non-Randomized, Controlled Trial
2013
The Autoimmune Disease-Associated Snp Rs917997 of Il18Rap Controls Ifn Gamma Production By Pbmc
Journal of Autoimmunity
2013
Evidence of a Strong Association Between Frequency of Self-Monitoring of Blood Glucose and Hemoglobin A(1C) Levels in T1D Exchange Clinic Registry Participants
Diabetes Care
2013
Autologous Umbilical Cord Blood Infusion Followed By Oral Docosahexaenoic Acid and Vitamin D Supplementation for C-Peptide Preservation in Children With Type 1 Diabetes
Biology of Blood and Marrow Transplantation
2013
Diabetic Ketoacidosis At Diabetes Onset: Still An All Too Common Threat in Youth
Journal of Pediatrics
2012
Characteristics of Thawed Autologous Umbilical Cord Blood
Transfusion
2012
Tanner Stage 4 Breast Development in Adults: Forensic Implications
Pediatrics
2012
Through the Fog: Recent Clinical Trials To Preserve Beta-Cell Function in Type 1 Diabetes
Diabetes
2012
Type 1 Diabetes: Current Concepts in Epidemiology, Pathophysiology, Clinical Care, and Research
Current Problems in Pediatric and Adolescent Health Care
2012
Update On Global Intervention Studies in Type 1 Diabetes
Endocrinology and Metabolism Clinics of North America
2011
Autologous Umbilical Cord Blood Transfusion in Young Children With Type 1 Diabetes Fails To Preserve C-Peptide
Diabetes Care
2011
Development of Autoantibodies in the Trialnet Natural History Study
Diabetes Care
2011
Islet Autoantibody Seroconversion in the Dpt-1 Study Justification for Repeat Screening Throughout Childhood
Diabetes Care
2011
Loss of Intra-Islet Cd20 Expression May Complicate Efficacy of B-Cell-Directed Type 1 Diabetes Therapies
Diabetes
2011
Reduced Prevalence of Diabetic Ketoacidosis At Diagnosis of Type 1 Diabetes in Young Children Participating in Longitudinal Follow-Up
Diabetes Care
2011
Reduced Serum Vitamin D-Binding Protein Levels Are Associated With Type 1 Diabetes
Diabetes
2011
Use of a Precious Resource: Parental Decision Making About Using Autologous Umbilical Cord Blood in Studies Involving Young Children With Type 1 Diabetes
Contemporary Clinical Trials
2011
Progressive Erosion of Beta-Cell Function Precedes the Onset of Hyperglycemia in the Nod Mouse Model of Type 1 Diabetes
Diabetes
2010
Arterial Stiffness, Lipoprotein Particle Size, and Lipoprotein Particle Concentration in Children With Type 1 Diabetes
Journal of Pediatric Endocrinology & Metabolism
2010
Coronary Artery Disease in Youth: Present Markers, Future Hope?
Journal of Pediatrics
2010
Efforts To Prevent and Halt Autoimmune Beta Cell Destruction
Endocrinology and Metabolism Clinics of North America
2010
Exendin-4 Treatment of Nonobese Diabetic Mice Increases Beta-Cell Proliferation and Fractional Insulin Reactive Area
Journal of Diabetes and Its Complications
2010
Intradermal Alpha 1-Antitrypsin Therapy Avoids Fatal Anaphylaxis, Prevents Type 1 Diabetes and Reverses Hyperglycaemia in the Nod Mouse Model of the Disease
Diabetologia
2010
Type I diabetes. Preface.
Endocrinology and Metabolism Clinics of North America
2009
Vitamin D Levels in Subjets With and Without Type 1 Diabetes Residing in a Solar Rich Environment
Diabetes Care
2009
Vascular Dysfunction in Glycogen Storage Disease Type I
Journal of Pediatrics
2009
Serum Monocyte Chemoattractant Protein-1 Concentrations Associate With Diabetes Status But Not Arterial Stiffness in Children With Type 1 Diabetes
Diabetes Care
2009
Seroconversion in the Dpt-1 Study: Evidence of Triggering of Autoimmune Process At Different Ages
2009
Pediatric Atorvastatin in Diabetes Trial (PADIT): a pilot study to determine the effect of atorvastatin on arterial stiffness and endothelial function in children with type 1 diabetes mellitus.
Journal of Pediatric Endocrinology & Metabolism
2009
The road not taken: a path to curing type 1 diabetes?
European Journal of Immunology
2009
In Pursuit of Lower A1C
Journal of Pediatrics
2009
Immune Depletion With Cellular Mobilization Imparts Immunoregulation and Reverses Autoimmune Diabetes in Nonobese Diabetic Mice
Diabetes
2009
Autologous Umbilical Cord Blood Transfusion in Very Young Children With Type 1 Diabetes
Diabetes Care
2009
Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus
Jama-Journal of the American Medical Association
2009
Atorvastatin Differentially Affects Serum and Leukocyte Mcp-1 Concentrations With No Contribution From Nos3 Gene Variation.
Clinical Pharmacology & Therapeutics
2009
Pediatric Atorvastatin in Diabetes Trial (Padit): a Pilot Study To Determine the Effect of Atorvastatin On Arterial Stiffness and Endothelial Function in Children With Type 1 Diabetes Mellitus
Journal of Pediatric Endocrinology & Metabolism
2008
Type 1 Diabetes Associated With Acquired Generalized Lipodystrophy and Insulin Resistance: the Effect of Long-Term Leptin Therapy
The Journal of Clinical Endocrinology and Metabolism
2008
Exendin-4 Therapy in Nod Mice With New-Onset Diabetes Increases Regulatory T Cell Frequency
2008
What'S in a Name? Thyroid Autoimmunity in Obese Patients With T1D
2008
Characteristics and Cell Compostion of Privately Banked Autologous Umbilical Cord Blood (Ucb) Units Utilized for Autologous Ucb Infusion in Children With Type I Diabetes
Biology of Blood and Marrow Transplantation
2008
Autologous Umbilical Cord Blood Infusion for Type 1 Diabetes
Experimental Hematology
2008
Cytokines and Type 1 Diabetes Complications: Casual Or Causal Association?
2007
Adverse impact of temperature and humidity on blood glucose monitoring reliability: a pilot study.
Diabetes Technology & Therapeutics
2007
Endocrine complications of childhood cancer therapy: evaluation and management.
Pediatric endocrinology reviews : PER
2007
No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes
Diabetes
2007
Peripheral artery tonometry demonstrates altered endothelial function in children with type 1 diabetes.
2007
Type 1 diabetes intervention trials 2007: where are we and where are we going?
Current Opinion in Endocrinology & Diabetes
2006
Arterial thrombosis resulting in amputation in a child with poorly controlled type 1 diabetes and heterozygous Factor V Leiden mutation.
2006
Serum superoxide dismutase activity and nitric oxide do not correlate with arterial stiffness in children with type 1 diabetes mellitus.
Journal of Pediatric Endocrinology & Metabolism
2004
Blood lymphocyte chimerism associated with IVF and monochorionic dizygous twinning: case report.
2004
Predictors of control of diabetes: monitoring may be the key
Journal of Pediatrics
2004
Radial artery tonometry demonstrates arterial stiffness in children with type 1 diabetes.
Diabetes Care

Grants

Apr 2020 ACTIVE
Emergency Funding to Support Underserved T1D Populations Impacted by the COVID-19 Pandemic
HELMSLEY CHARITABLE TRUST, LEONA & HARRY · Principal Investigator
Feb 2020 ACTIVE
TrialNet Clinical Center infrastructure support services
UNIV OF SOUTH FLORIDA · Principal Investigator
Sep 2019 ACTIVE
Evaluation of the safety, tolerability and general response to Lactobacillus johnsonii N6.2 in children and adolescents with T1D
JDRF ·
Sep 2019 ACTIVE
Evaluation of safety, tolerability and immunological responses to Lactobacillus johnsonii N6.2 supplementation in adults with Diabetes type 1
NATL INST OF HLTH NIDDK ·
Jul 2019 ACTIVE
Project ECHO T1D: HCT Trial
STANFORD UNIV · Principal Investigator
Apr 2019 ACTIVE
Data Coordinating Center for the Consortium for Identification of Environmental Determinants of Diabetes in the Young (TEDDY) Study
AUGUSTA UNIVERSITY · Principal Investigator
Oct 2018 ACTIVE
T cell receptor sequencing in type 1 diabetes – biomarker discovery and technology development
HELMSLEY CHARITABLE TRUST, LEONA & HARRY ·
Aug 2018 ACTIVE
Introducing Continuous Glucose Monitoring Technology at Diagnosis in Pediatric Type 1 Diabetes: A proof of Concept Study.
DIABETES ACTION RESEARCH AND EDU FOU · Mentor
Jun 2018 ACTIVE
Immune Function and the Progression to Type 1 Diabetes
NATL INST OF HLTH NIAID ·
Jun 2018 – Jun 2019
Characterization of T cell Autoreactivity in Type 1 Diabetes
JDRF ·
Apr 2018 – Mar 2019
Data Coordinating Center (TEDDY)
AUGUSTA UNIVERSITY · Principal Investigator
Mar 2018 – Apr 2019
Pediatric Endocrine Society Travel Award
PEDIATRIC ENDOCRINE SOCIETY · Mentor
Jan 2018 – Jun 2019
ECHO Type 1 Diabetes: A Feasibility and Planning Proposal
HELMSLEY CHARITABLE TRUST, LEONA & HARRY · Principal Investigator
Jan 2018 – Mar 2018
Data Coordinating Center for the Consortium for Identification of Environmental Determinants of Diabetes in the Young (TEDDY) Study
AUGUSTA UNIVERSITY · Principal Investigator
Jan 2018 – Dec 2019
Hybrid Closed Loop Insulin Delivery System Data Collection (HYCLO)
JAEB CTR FOR HLTH RES · Principal Investigator
Dec 2017 ACTIVE
McJunkin Family Foundation Diabetes
UF FOU · Principal Investigator
Sep 2017 – Nov 2018
Young Adult Racial Disparities in Type 1 Diabetes (YARDD)
JAEB CTR FOR HLTH RES · Mentor
Sep 2017 – Oct 2018
Type 1 Diabetes EXercise Initiative (T1-Dexi) Steering Committee
JAEB CTR FOR HLTH RES · Principal Investigator
Aug 2017 – Jul 2018
Low-Dose IL-2 in Established T1D
UNIV OF MIAMI ·
Jul 2017 – Jun 2018
TrialNet Affiliate Services FY 17-18
UNIV OF SOUTH FLORIDA · Project Manager
Jul 2017 – May 2018
PES Travel Grant
PEDIATRIC ENDOCRINE SOCIETY · Mentor
Jun 2017 – Dec 2017
Pediatric Endocrine Society Travel Award
PEDIATRIC ENDOCRINE SOCIETY · Mentor
Apr 2017 ACTIVE
OoR CTSI Institutional Matching Support
UF DIV OF SPONSORED RES MATCHING FUNDS · Project Manager
Mar 2017 – Feb 2018
Estimating the Lifetime Costs of Type 1 Diabetes
BOSTON HEALTH ECONOMICS INC · Principal Investigator
Jan 2017 – Nov 2017
A Phase 3B Study to Evaluate the Glucose Response of G-Pen (Glucagon Injection) in Pediatric Patients with Type 1 Diabetes
EMMES CORP · Principal Investigator
Jul 2016 – Jan 2020
Strategies to Encourage CGM use in Young Children (SENCE)
INDIANA UNIV ·
Jul 2016 – Jun 2017
TrialNet Affiliate Services
UNIV OF SOUTH FLORIDA · Project Manager
Jun 2016 – Nov 2019
Clinical Trial Planning Grant for Treg Therapy in Type I Diabetes
CORD BLOOD REGISTRY · Principal Investigator
Jun 2016 – Dec 2017
Data Coordinating Center
AUGUSTA UNIVERSITY · Principal Investigator
Aug 2015 – Apr 2016
OPEN-LABEL, SINGLE-ARM, MULTIPLE-DOSE SAFETY, TITRATION,
SANOFI US SERVICES · Principal Investigator
Aug 2015 – Jul 2017
Reversing Type 1 Diabetes after it is Established: Follow up, Phase II
HELMSLEY CHARITABLE TRUST, LEONA & HARRY · Principal Investigator
Jul 2015 – Jun 2016
Trialnet affiliate services
UNIV OF SOUTH FLORIDA · Project Manager
Jan 2015 – Jul 2017
Cord Blood Expansion of Regulatory T cells
CBR SYSTEMS · Project Manager
Jan 2015 – Oct 2016
Dissociation of obesity and insulin sensitivity in 2 rar
GENENTECH INC · Principal Investigator
Jan 2015 – Dec 2016
Acute effect of a mixed meal with and without insulin on
DIABETES ACTION RESEARCH AND EDU FOU · Principal Investigator
Nov 2014 – Dec 2018
Antithymocyte Globulin (ATG) and pegylated granulocyte c
HELMSLEY CHARITABLE TRUST, LEONA & HARRY · Principal Investigator
Nov 2014 – May 2018
ATG GCSF – Sanofi
SANOFI US SERVICES · Principal Investigator
Sep 2014 – May 2016
Data Coordinating Center
*GEORGIA REGENTS UNIVERSITY · Principal Investigator
Jun 2014 – Apr 2020
TrialNet: University of Florida Clinical Center and Network
NATL INST OF HLTH NIDDK · Principal Investigator
Nov 2013 – Oct 2016
T1D Exchange Biobank
JAEB CTR FOR HLTH RES · Principal Investigator
Sep 2013 – Aug 2017
Pancreatic Volume in Preclinical Type 1 Diabetes
NATL INST OF HLTH NIDDK · Project Manager
Apr 2012 – Mar 2016
T1D Exchange: BRI Biobank Operations Center
BENAROYA RES INST AT VA MASON · Principal Investigator
Feb 2012 – Mar 2019
T1D Exchange Type 1 Diabetes Network Ancillary Study: R
JAEB CTR FOR HLTH RES · Principal Investigator
Jul 2007 – Aug 2016
CTSI
UF RESEARCH FOU · Project Manager

Education

Masters Clinical Investigation
2006 · University of Florida
Medical Degree
2000 · University of Florida
BS (Biology and Chemistry)
1996 · Duke University

Contact Details

Phones:
Business:
(352) 273-9264
Emails:
Business:
hallerms@ufl.edu
Addresses:
Mailing:
MICHAEL HALLER, MD
PO BOX 100296
 GAINESVILLE FL 326100296
Physical:
1600 SW ARCHER RD J591
 GAINESVILLE FL 32610